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Schema
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Reaction
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Entries
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
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authored
[InstanceEdit:5621479] Garapati, P V, 2014-08-29
catalystActivity
[CatalystActivity:5621361] protein tyrosine kinase activity of pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643739] protein tyrosine kinase activity of pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5621373] Garapati, P V, 2014-08-29
dbId
5621363
displayName
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
edited
[InstanceEdit:5621479] Garapati, P V, 2014-08-29
eventOf
[Pathway:R-HSA-5621480] Dectin-2 family - Homo sapiens
followingEvent
[Reaction:R-HSA-5621347] PLCG2 translocates from cytosol to plasma membrane - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:443435] Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
[LiteratureReference:5607371] Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
orthologousEvent
[Reaction:R-RNO-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Rattus norvegicus
[Reaction:R-GGA-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Gallus gallus
[Reaction:R-XTR-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Xenopus tropicalis
[Reaction:R-DRE-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Danio rerio
[Reaction:R-SSC-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Sus scrofa
[Reaction:R-BTA-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Bos taurus
[Reaction:R-CFA-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Canis familiaris
[Reaction:R-MMU-5621363] SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-5621158] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G - Homo sapiens
releaseDate
2015-03-19
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5621363
summation
[Summation:5621364] Activation of SYK triggers multiple cascades, which induces ...
Referrals
(hasEvent)
[Pathway:R-HSA-5621480] Dectin-2 family
(precedingEvent)
[Reaction:R-HSA-5621347] PLCG2 translocates from cytosol to plasma membrane
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