Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)

Stable Identifier
Homo sapiens
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The human gene SLC22A18 (aka TSSC5) encodes organic cation transporter-like protein 2 (ORCTL2). It is expressed at high levels in kidney, liver and colon and at lower levels in heart, brain and lung. ORCTL2 can transport organic cations such as chloroquine and quinidine with the antiport of protons.

The human chromosome region 11p15.5 is linked with Beckwith-Wiedemann syndrome (associated with susceptibility to Wilms' tumor, rhabdomyosarcoma and hepatoblastoma). SLC22A18 is located in this region (Cooper et al. 1998, Lee et al. 1998). Mutations and/or reduced expression of SLC22A18 have been found in certain tumors such as lung cancer (LNCR; MIM:211980) (Lee et al. 1998) and embryonal rhabdomyosarcoma 1 (RMSE1; MIM:268210) (Schwienbacher et al. 1998). How SLC22A18 might be involved in growth regulation is poorly understood. There is speculation that it may be involved in resistance to chemotherapy drugs and/or in the export of genotoxic substances whose retention may increase the risk of tumor formation.
Literature References
PubMed ID Title Journal Year
9520460 Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples

Ohashi, H, Campi, M, Schwienbacher, C, Croce, CM, Mukai, T, Menegatti, A, Hatada, I, Veronese, A, Barbanti-Brodano, G, Bernardi, G, Sabbioni, S, Negrini, M

Proc Natl Acad Sci U S A 1998
9570947 Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain

Reid, LH, Shows, TB, Cooper, PR, Higgins, MJ, Landers, J, Prawitt, D, Nowak, NJ, Pelletier, J, Housman, DE, Reece, M, Day, CD, Smilinich, NJ, Weissman, BE, Winterpacht, A, Zabel, BU, Pearsall, RS

Genomics 1998
9751628 Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5

Miller, G, Lee, MJ, Feinberg, AP, Brandenburg, S, Hu, RJ, Reeves, C, Connors, TD, Su, K, Schmitt, A, Lee, MP

Cancer Res. 1998
Name Identifier Synonyms
lung cancer DOID:1324
rhabdomyosarcoma DOID:3247 Rhabdomyosarcoma NOS (morphologic abnormality), rhabdomyosarcoma, Rhabdomyosarcoma, no subtype (morphologic abnormality), rhabdomyoblastoma, Rhabdomyosarcoma (disorder)
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