Reactome | Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+

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Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ Show undefined attributes

authored	[InstanceEdit:5625590] Jassal, Bijay, 2014-10-06
catalystActivity	[CatalystActivity:9631772] xenobiotic transmembrane transporter activity of SLC22A18 mutants [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5625590] Jassal, Bijay, 2014-10-06
crossReference	[DatabaseIdentifier:12020755] Mondo:0008903
dbId	5625574
disease	[Disease:1500699] lung cancer [Disease:1614291] rhabdomyosarcoma
displayName	Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+
edited	[InstanceEdit:5625590] Jassal, Bijay, 2014-10-06
entityFunctionalStatus	[EntityFunctionalStatus:5625578] loss_of_function of SLC22A18 mutants [plasma membrane]
eventOf	[Pathway:R-HSA-5619066] Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-597604] SLC22A18 substrates [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5625587] Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5 [LiteratureReference:597602] Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+
normalReaction	[Reaction:R-HSA-597628] SLC22A18 exchanges extracellular organic cations for cytosolic H+
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6789776] Broer, Stefan, 2015-08-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5625574
summation	[Summation:5625602] The human gene SLC22A18 (aka TSSC5) encodes organic cation t...
updateTrackers	[UpdateTracker:9778335] Update Tracker - [FailedReaction:5625574] Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9778335] Update Tracker - [FailedReaction:5625574] Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-5619066] Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)

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