Reactome | SCF(beta-TrCP) ubiquitinates p-GLI2

Schema > Reaction > Entries

SCF(beta-TrCP) ubiquitinates p-GLI2 Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:208937] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
category	transition
compartment	[Compartment:5263232] ciliary base
created	[InstanceEdit:5610744] Rothfels, Karen, 2014-07-22
dbId	5610745
displayName	SCF(beta-TrCP) ubiquitinates p-GLI2
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610783] Degradation of GLI2 by the proteasome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5610757] GLI2 is degraded by the proteasome - Homo sapiens
inferredFrom	[Reaction:R-NUL-5610711] SCF(beta-TrCP) ubiquitinates p-Gli2 - Homo sapiens
input	[Complex:R-HSA-5610584] p11S-GLI2:SUFU [ciliary base] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5609843] Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SCF(beta-TrCP) ubiquitinates p-GLI2
output	[Complex:R-HSA-5610608] ub-p11S-GLI2:SUFU [ciliary base]
precedingEvent	[Reaction:R-HSA-5610730] GSK3 phosphorylates p-GLI2 - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5610745
summation	[Summation:5610661] GLI2 interacts directly with beta-TrCP and is polyubiquitina...

Referrals

(hasEvent)	[Pathway:R-HSA-5610783] Degradation of GLI2 by the proteasome
(precedingEvent)	[BlackBoxEvent:R-HSA-5610757] GLI2 is degraded by the proteasome
(inferredTo)	[Reaction:R-NUL-5610711] SCF(beta-TrCP) ubiquitinates p-Gli2

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