Reactome | SCF(beta-TrCP) ubiquitinates p-Gli2

Schema > Reaction > Entries

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:5610641] ubiquitin-protein transferase activity of Btrc,Fbxw11 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5610712] Rothfels, Karen, 2014-07-22
dbId	5610711
displayName	SCF(beta-TrCP) ubiquitinates p-Gli2
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
input	[Complex:R-MMU-5610586] p11S-Gli2:Sufu [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609843] Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SCF(beta-TrCP) ubiquitinates p-Gli2
orthologousEvent	[Reaction:R-HSA-5610745] SCF(beta-TrCP) ubiquitinates p-GLI2 - Homo sapiens
output	[Complex:R-MMU-5610609] ub-p11S-Gli2:Sufu [cytosol]
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stId	R-NUL-5610711
summation	[Summation:5610707] mGli2 is polyubiquitinated when overexpressed in HEK293 cell...

Cite Us!