Expression of FABP4 (aP2)

Stable Identifier
R-HSA-560510
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, lipid droplet
ReviewStatus
5/5
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Expression of FABP4 (aP2)
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As inferred from mouse, Cdk4 interacts with PPARG and enhances transcription. Binding of the two factors was tested on the FABP4 (aP2) promoter. The PPARG:RXRA heterodimer bound to fatty acids activates transcription of FABP4 (aP2). In mouse the Pparg:Rxra heterodimer directly binds the promoter of the Fabp4 gene (Grontveld et al. 2010, Ge et al. 2008, Lefterova et al. 2008) As inferred from mouse, CyclinD3 interacts with PPARG and enhances transcription. Binding of the two factors was tested on the FABP4 (aP2) promoter. The FABP4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Expression of FABP4 is activated during adipogenesis.
Literature References
PubMed ID Title Journal Year
20101261 Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression

Morganstein, DL, Wu, P, Mane, MR, Fisk, NM, White, R, Parker, MG

Cell Res 2010
15273253 Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands

Rival, Y, Stennevin, A, Puech, L, Rouquette, A, Cathala, C, Lestienne, F, Dupont-Passelaigue, E, Patoiseau, JF, Wurch, T, Junquéro, D

J Pharmacol Exp Ther 2004
19115207 A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells

Boiteux, G, Lascombe, I, Roche, E, Plissonnier, ML, Clairotte, A, Bittard, H, Fauconnet, S

Int J Cancer 2009
10425206 PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes

Pelton, PD, Zhou, L, Demarest, KT, Burris, TP

Biochem Biophys Res Commun 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CDK4 [nucleoplasm] (Homo sapiens)
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Regulator
CCND3 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-03-23)
Reviewed
D'Eustachio, P  (2009-05-27)
Sethi, JK  (2011-02-10)
Created
May, B  (2010-03-24)
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