Reactome | Activated protein C binds Protein S

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Activated protein C binds Protein S Show undefined attributes

authored	[InstanceEdit:5607780] Jupe, Steve, 2014-07-14
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5604923] Jupe, Steve, 2014-07-02
dbId	5604929
displayName	Activated protein C binds Protein S
edited	[InstanceEdit:5627264] Jupe, Steve, 2014-07-28
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-141004] 11xCbxE-PROS1 [plasma membrane] [Complex:R-HSA-141050] Activated protein C [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5604924] Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated protein C binds Protein S
orthologousEvent	[Reaction:R-GGA-5604929] Activated protein C binds Protein S - Gallus gallus [Reaction:R-XTR-5604929] Activated protein C binds Protein S - Xenopus tropicalis [Reaction:R-DRE-5604929] Activated protein C binds Protein S - Danio rerio [Reaction:R-SSC-5604929] Activated protein C binds Protein S - Sus scrofa [Reaction:R-BTA-5604929] Activated protein C binds Protein S - Bos taurus [Reaction:R-CFA-5604929] Activated protein C binds Protein S - Canis familiaris [Reaction:R-RNO-5604929] Activated protein C binds Protein S - Rattus norvegicus [Reaction:R-MMU-5604929] Activated protein C binds Protein S - Mus musculus
output	[Complex:R-HSA-5604926] Activated protein C:Protein S [plasma membrane]
precedingEvent	[Reaction:R-HSA-5603467] Activated protein C is released from PROCR - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5627265] Mumford, Andrew, 2014-09-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5604929
summation	[Summation:5604931] Activated protein C binds to Protein S on appropriate cell s...
systematicName	Activated protein C binds 11xCbxE-PROS1
updateTrackers	[UpdateTracker:9939739] Update Tracker - [Reaction:5604929] Activated protein C binds Protein S - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939739] Update Tracker - [Reaction:5604929] Activated protein C binds Protein S - v92:[modifyText]
(precedingEvent)	[Reaction:R-HSA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form
(hasEvent)	[Pathway:R-HSA-9769739] Regulation of clotting cascade

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