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Schema
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Reaction
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Entries
Activated protein C cleaves factor Va to factor Vi intermediate form
Show undefined attributes
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authored
[InstanceEdit:140993] D'Eustachio, P, 2004-08-26 13:13:00
catalystActivity
[CatalystActivity:141025] serine-type endopeptidase activity of Activated protein C:Protein S [plasma membrane]
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:140993] D'Eustachio, P, 2004-08-26 13:13:00
dbId
141026
diseaseReaction
[FailedReaction:R-HSA-9930452] F5 R534Q, A540V is not cleaved by activated protein C - Homo sapiens
displayName
Activated protein C cleaves factor Va to factor Vi intermediate form
eventOf
[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
followingEvent
[Reaction:R-HSA-5591040] Activated protein C cleaves Factor Va intermediate form for Factor Va - Homo sapiens
input
[Complex:R-HSA-140692] factor Va [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:141028] The roles of protein C and thrombomodulin in the regulation of blood coagulation
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
Activated protein C cleaves factor Va to factor Vi intermediate form
factor Va -> factor Vi
orthologousEvent
[Reaction:R-GGA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Gallus gallus
[Reaction:R-DRE-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Danio rerio
[Reaction:R-SSC-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Sus scrofa
[Reaction:R-BTA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Bos taurus
[Reaction:R-CFA-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Canis familiaris
[Reaction:R-MMU-141026] Activated protein C cleaves factor Va to factor Vi intermediate form - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-5605103] F5(535-737) [extracellular region]
[Complex:R-HSA-141055] factor Vi intermediate form [extracellular region]
precedingEvent
[Reaction:R-HSA-5604929] Activated protein C binds Protein S - Homo sapiens
releaseDate
2004-10-27
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-141026
summation
[Summation:141027] Activated protein C (APC) cleaves peptide bonds in activated...
updateTrackers
[UpdateTracker:9939816] Update Tracker - [Reaction:141026] Activated protein C cleaves factor Va to factor Vi intermediate form - v92:[modifyText]
[UpdateTracker:9786088] Update Tracker - [Reaction:141026] Activated protein C cleaves factor Va to factor Vi intermediate form - v50:[addOutput, modifyText, removeRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9939816] Update Tracker - [Reaction:141026] Activated protein C cleaves factor Va to factor Vi intermediate form - v92:[modifyText]
[UpdateTracker:9786088] Update Tracker - [Reaction:141026] Activated protein C cleaves factor Va to factor Vi intermediate form - v50:[addOutput, modifyText, removeRegulator]
(normalReaction)
[FailedReaction:R-HSA-9930452] F5 R534Q, A540V is not cleaved by activated protein C
(hasEvent)
[Pathway:R-HSA-9769739] Regulation of clotting cascade
(precedingEvent)
[Reaction:R-HSA-5591040] Activated protein C cleaves Factor Va intermediate form for Factor Va
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