Activated protein C binds Protein S

Stable Identifier
R-HSA-5604929
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Activated protein C binds Protein S
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Activated protein C binds to Protein S on appropriate cell surfaces where it inactivates factors Va and VIIIa.
Protein S is best known as a cofactor for the Activated protein C (APC)-catalyzed inactivation of factor Va (Walker 1980). Protein S must be membrane-bound to display this cofactor activity (Hackeng et al. 1993). Protein S binding brings the active site of APC closer to the phospholipid cell surface (Yegneswaran et al. 1999).
Literature References
PubMed ID Title Journal Year
10026158 Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study

Yegneswaran, S, Smirnov, MD, Safa, O, Esmon, NL, Esmon, CT, Johnson, AE

J. Biol. Chem. 1999
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Authored
Jupe, S  (2014-07-14)
Reviewed
Mumford, D  (2014-09-11)
Created
Jupe, S  (2014-07-02)
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