Reactome | Defective MyD88 does not oligomerize within the complex of activated TLR5

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Defective MyD88 does not oligomerize within the complex of activated TLR5 Show undefined attributes

authored	[InstanceEdit:5545427] Shamovsky, V, 2014-05-21
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5602721] Shamovsky, Veronica, 2014-06-24
crossReference	[DatabaseIdentifier:12021025] Mondo:0003778
dbId	5602316
disease	[Disease:5228860] primary immunodeficiency disease
displayName	Defective MyD88 does not oligomerize within the complex of activated TLR5
edited	[InstanceEdit:5673719] Shamovsky, Veronica, 2015-02-09
entityFunctionalStatus	[EntityFunctionalStatus:5602376] loss_of_function of MyD88 variants [cytosol] [EntityFunctionalStatus:9658484] loss_of_function of MyD88 variant:TLR5:bacterial flagellin [plasma membrane]
eventOf	[Pathway:R-HSA-5602680] MyD88 deficiency (TLR5) - Homo sapiens
input	[Complex:R-HSA-9037690] MyD88 variant:TLR5:bacterial flagellin [plasma membrane] 4 × [CandidateSet:R-HSA-5602754] MyD88 variants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5602389] Pyogenic bacterial infections in humans with MyD88 deficiency [LiteratureReference:2428864] Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective MyD88 does not oligomerize within the complex of activated TLR5
normalReaction	[Reaction:R-HSA-975880] MyD88 oligomerization within the complex of activated TLR:MyD88
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621924] D'Eustachio, Peter, 2014-09-06 [InstanceEdit:5675062] McDonald, Douglas R, 2015-02-15
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5602316
summation	[Summation:5607932] TLR5 employs the MyD88-dependent signaling pathway. An autos...
systematicName	Defective MyD88 variants do not form a complex with IRAK4, TLR5 homodimer:bacterial flagellin
updateTrackers	[UpdateTracker:9780090] Update Tracker - [FailedReaction:5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - v64:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9780090] Update Tracker - [FailedReaction:5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - v64:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-5602680] MyD88 deficiency (TLR5)

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