Reactome | MyD88 variants [cytosol]

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MyD88 variants [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9037690] MyD88 variant:TLR5:bacterial flagellin [plasma membrane] - Homo sapiens [Complex:R-HSA-9037690] MyD88 variant:TLR5:bacterial flagellin [plasma membrane] - Homo sapiens [Complex:R-HSA-9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - Homo sapiens [Complex:R-HSA-9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - Homo sapiens [FailedReaction:R-HSA-5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - Homo sapiens [FailedReaction:R-HSA-5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - Homo sapiens [FailedReaction:R-HSA-5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - Homo sapiens [FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - Homo sapiens [FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - Homo sapiens [FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - Homo sapiens [FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex - Homo sapiens
created	[InstanceEdit:5602721] Shamovsky, Veronica, 2014-06-24
crossReference	[DatabaseIdentifier:12021025] Mondo:0003778
dbId	5602754
disease	[Disease:5228860] primary immunodeficiency disease
displayName	MyD88 variants [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-5602521] MyD88 S34Y [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5602598] MyD88 E65del [cytosol] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-5602451] MyD88 E52del [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5602612] MyD88 L93P [cytosol] - Homo sapiens
inDisease	true
maxDepth	2
name	MyD88 variants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-5602754

Referrals

(input)	[FailedReaction:R-HSA-5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 [FailedReaction:R-HSA-5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex
(hasComponent)	[Complex:R-HSA-9037690] MyD88 variant:TLR5:bacterial flagellin [plasma membrane] [Complex:R-HSA-9037685] MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane]
(diseaseEntity)	[EntityFunctionalStatus:5602376] loss_of_function of MyD88 variants [cytosol]

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