Reactome | Defective Mismatch Repair Associated With MSH2

Schema > Pathway > Entries

authored	[InstanceEdit:1981184] Gillespie, ME, 2011-11-09
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5632929] Gillespie, Marc E, 2014-10-29
dbId	5632928
disease	[Disease:1500689] cancer
displayName	Defective Mismatch Repair Associated With MSH2
edited	[InstanceEdit:8980077] Gillespie, Marc E, 2017-02-27
eventOf	[Pathway:R-HSA-5423599] Diseases of Mismatch Repair (MMR) - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-5577244] MSH2 variant:MSH6-defective DNA mismatch repair - Homo sapiens [FailedReaction:R-HSA-5577259] MSH2 variant:MSH3-defective DNA mismatch repair - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5575583] Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review [LiteratureReference:3642271] The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective Mismatch Repair Associated With MSH2
normalPathway	[Pathway:R-HSA-5358508] Mismatch Repair
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8944056] Arora, Sanjeevani, 2016-11-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5632928
summation	[Summation:5633020] MSH2 is homologous to the E. coli MutS gene and is involved ...

(hasEvent)

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