OCT1 transports organic cations out of hepatic cells

Stable Identifier
R-HSA-549322
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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OCT1 transports organic cations out of hepatic cells
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The human gene SLC22A1 expresses the organic cation transporter 1 (OCT1) mainly in the liver. It can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Zhang L et al, 1998; Gorboulev V et al, 1997).
Literature References
PubMed ID Title Journal Year
9260930 Cloning and characterization of two human polyspecific organic cation transporters

Gorboulev, V, Ulzheimer, JC, Akhoundova, A, Ulzheimer-Teuber, I, Karbach, U, Quester, S, Baumann, C, Lang, F, Busch, AE, Koepsell, H

DNA Cell Biol 1997
9655880 Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)

Zhang, L, Schaner, ME, Giacomini, KM

J Pharmacol Exp Ther 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

transmembrane transporter activity of OCT1 [plasma membrane]

Physical Entity
OCT1 [plasma membrane] (Homo sapiens)
Activity
transmembrane transporter activity (GO:0022857)
Orthologous Events
OCT1 transports organic cations out of hepatic cells (Bos taurus)
OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)
OCT1 transports organic cations out of hepatic cells (Canis familiaris)
OCT1 transports organic cations out of hepatic cells (Danio rerio)
OCT1 transports organic cations out of hepatic cells (Drosophila melanogaster)
OCT1 transports organic cations out of hepatic cells (Gallus gallus)
OCT1 transports organic cations out of hepatic cells (Mus musculus)
OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)
OCT1 transports organic cations out of hepatic cells (Sus scrofa)
OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2010-03-19)
Reviewed
He, L  (2010-05-10)
Created
Jassal, B  (2010-03-19)
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