UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b

Stable Identifier
R-HSA-548884
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum quality control compartment
Synonyms
Re-addition of a glucose on the alpha 1,3 branch
ReviewStatus
5/5
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UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b
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The UDP-glucose:glycoprotein glucosyltransferases 1 and 2 (UGGT1 and 2) are able to distinguish proteins with minor folding defects in the ERQC and reglucosylate them, by transferring a glucose (from dolichyl beta-D-glucosyl phosphate, DbGP) onto the alpha 1,3 mannose of the b (or c, not shown here) branch (Arnold et al. 2000, Arnold et al. 2003). The major affinity of these enzymes for proteins with minor folding defects has been demonstrated, but the exact mechanism that enable them to distinguish proteins with major and minor defects is still unknown (Pearse et al. 2008).
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Catalyst Activity

UDP-glucose:glycoprotein glucosyltransferase activity of UGGT1,2 [endoplasmic reticulum lumen]

Physical Entity
UGGT1,2 [endoplasmic reticulum lumen] (Homo sapiens)
Activity
UDP-glucose:glycoprotein glucosyltransferase activity (GO:0003980)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-11-18)
Created
Jassal, B  (2010-03-15)
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