Reactome | ACSL3,4 ligate CoA to AA to form AA-CoA

Schema > Reaction > Entries

ACSL3,4 ligate CoA to AA to form AA-CoA Show undefined attributes

authored	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
catalystActivity	[CatalystActivity:548838] long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643588] long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane] A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:548837] D'Eustachio, P, 2010-03-14
crossReference	[DatabaseIdentifier:12668383] RHEA:19714
dbId	548843
displayName	ACSL3,4 ligate CoA to AA to form AA-CoA
edited	[InstanceEdit:548846] D'Eustachio, P, 2010-03-14
eventOf	[Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs - Homo sapiens
followingEvent	[Reaction:R-HSA-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:548713] A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients [LiteratureReference:548702] FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation [LiteratureReference:5676169] Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ACSL3,4 ligate CoA to AA to form AA-CoA arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
orthologousEvent	[Reaction:R-SCE-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Schizosaccharomyces pombe [Reaction:R-CEL-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Caenorhabditis elegans [Reaction:R-DME-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Drosophila melanogaster [Reaction:R-GGA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Gallus gallus [Reaction:R-XTR-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Xenopus tropicalis [Reaction:R-DRE-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Danio rerio [Reaction:R-SSC-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Sus scrofa [Reaction:R-BTA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Bos taurus [Reaction:R-CFA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Canis familiaris [Reaction:R-RNO-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Rattus norvegicus [Reaction:R-MMU-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Mus musculus
output	[SimpleEntity:R-ALL-548819] AA-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5678222] D'Eustachio, Peter, 2015-02-21
revised	[InstanceEdit:5676160] Jassal, Bijay, 2015-02-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-548843
summation	[Summation:548799] Acyl-CoA synthetase long-chain family member 4 (ACSL4) assoc...
updateTrackers	[UpdateTracker:9785086] Update Tracker - [Reaction:548843] ACSL3,4 ligate CoA to AA to form AA-CoA - v52:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785086] Update Tracker - [Reaction:548843] ACSL3,4 ligate CoA to AA to form AA-CoA - v52:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA
(hasEvent)	[Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs

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