Reactome | ACSL3,4 ligate CoA to AA to form AA-CoA

Schema > Reaction > Entries

ACSL3,4 ligate CoA to AA to form AA-CoA Show undefined attributes

catalystActivity	[CatalystActivity:11089947] long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11089949
displayName	ACSL3,4 ligate CoA to AA to form AA-CoA
eventOf	[Pathway:R-SCE-75876] Synthesis of very long-chain fatty acyl-CoAs - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSL3,4 ligate CoA to AA to form AA-CoA arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
output	[SimpleEntity:R-ALL-548819] AA-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-548843
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-75876] Synthesis of very long-chain fatty acyl-CoAs
(inferredTo)	[Reaction:R-HSA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA

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