Reactome | ACSL3,4 ligate CoA to AA to form AA-CoA

Schema > Reaction > Entries

ACSL3,4 ligate CoA to AA to form AA-CoA Show undefined attributes

catalystActivity	[CatalystActivity:9899934] long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9899936
displayName	ACSL3,4 ligate CoA to AA to form AA-CoA
eventOf	[Pathway:R-MMU-75876] Synthesis of very long-chain fatty acyl-CoAs - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - Mus musculus
inferredFrom	[Reaction:R-HSA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
isInDisease	false
isInferred	true
name	ACSL3,4 ligate CoA to AA to form AA-CoA arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
output	[SimpleEntity:R-ALL-548819] AA-CoA [cytosol] [SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-548843
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-75876] Synthesis of very long-chain fatty acyl-CoAs
(precedingEvent)	[Reaction:R-MMU-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA
(inferredTo)	[Reaction:R-HSA-548843] ACSL3,4 ligate CoA to AA to form AA-CoA

Cite Us!