Reactome | Formation of MSH2:MSH3 Complex

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Formation of MSH2:MSH3 Complex Show undefined attributes

authored	[InstanceEdit:5423600] Gillespie, Marc E, 2014-05-09
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5444519] Gillespie, Marc E, 2014-05-14
dbId	5444511
diseaseReaction	[FailedReaction:R-HSA-5578663] MSH3 variant:MSH2-defective DNA mismatch repair - Homo sapiens [FailedReaction:R-HSA-5577259] MSH2 variant:MSH3-defective DNA mismatch repair - Homo sapiens
displayName	Formation of MSH2:MSH3 Complex
edited	[InstanceEdit:8980657] Gillespie, Marc E, 2017-02-28
eventOf	[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Homo sapiens
followingEvent	[Reaction:R-HSA-5358513] MSH2:MSH3 binds insertion/deletion loop of 2 bases or more - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5357525] MSH2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5357519] MSH3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5444524] Mutation of a mutL homolog in hereditary colon cancer
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Formation of MSH2:MSH3 Complex
orthologousEvent	[Reaction:R-SCE-5444511] Formation of MSH2:MSH3 Complex - Saccharomyces cerevisiae [Reaction:R-SPO-5444511] Formation of MSH2:MSH3 Complex - Schizosaccharomyces pombe [Reaction:R-GGA-5444511] Formation of MSH2:MSH3 Complex - Gallus gallus [Reaction:R-XTR-5444511] Formation of MSH2:MSH3 Complex - Xenopus tropicalis [Reaction:R-SSC-5444511] Formation of MSH2:MSH3 Complex - Sus scrofa [Reaction:R-BTA-5444511] Formation of MSH2:MSH3 Complex - Bos taurus [Reaction:R-CFA-5444511] Formation of MSH2:MSH3 Complex - Canis familiaris [Reaction:R-MMU-5444511] Formation of MSH2:MSH3 Complex - Mus musculus
output	[Complex:R-HSA-5357508] MSH2:MSH3:ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6806394] TP53 and AP-1 stimulate MSH2 expression - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5444511
summation	[Summation:6790096] MSH2 is homologous to the E. coli MutS gene and is involved ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5578663] MSH3 variant:MSH2-defective DNA mismatch repair [FailedReaction:R-HSA-5577259] MSH2 variant:MSH3-defective DNA mismatch repair
(hasEvent)	[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
(precedingEvent)	[Reaction:R-HSA-5358513] MSH2:MSH3 binds insertion/deletion loop of 2 bases or more