Reactome | MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA

MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA

Stable Identifier

R-HSA-5419264

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

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MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA

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MTRF1L (mtRF1a) binds the stop codons UAA and UAG of the mRNA when they are in the A site of the ribosome (Soleimanpour-Lichaei 2007, Nozaki et al. 2008). (The UGA codon is recognized by the tryptophan tRNA in mitochondrial translation.) ICT1 can also bind standard stop codons in the A-site (inferred from pig mitochondrial ribosomes in Akabane et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
18429816	HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG Nozaki, Y, Matsunaga, N, Ishizawa, T, Ueda, T, Takeuchi, N	Genes Cells	2008
17803939	mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG Soleimanpour-Lichaei, HR, Kühl, I, Gaisne, M, Passos, JF, Wydro, M, Rorbach, J, Temperley, R, Bonnefoy, N, Tate, W, Lightowlers, R, Chrzanowska-Lightowlers, ZM	Mol. Cell	2007