Reactome | C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane

Schema > Reaction > Entries

C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane Show undefined attributes

authored	[InstanceEdit:5359176] Rothfels, Karen, 2014-04-08
category	binding
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5362440] Rothfels, Karen, 2014-04-15
dbId	5362441
displayName	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
edited	[InstanceEdit:5364056] D'Eustachio, Peter, 2014-04-19
eventOf	[Pathway:R-HSA-5358346] Hedgehog ligand biogenesis - Homo sapiens
followingEvent	[Reaction:R-HSA-5362412] SYVN1 ubiquitinates Hh C-terminal fragments - Homo sapiens
input	[Complex:R-HSA-5362409] C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] [Complex:R-HSA-5362378] SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5359168] OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD [LiteratureReference:5359157] Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP [LiteratureReference:5359174] SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins [LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum [LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
orthologousEvent	[Reaction:R-DME-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Drosophila melanogaster [Reaction:R-GGA-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Gallus gallus [Reaction:R-XTR-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Xenopus tropicalis [Reaction:R-DRE-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Danio rerio [Reaction:R-SSC-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Sus scrofa [Reaction:R-BTA-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Bos taurus [Reaction:R-CFA-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Canis familiaris [Reaction:R-RNO-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Rattus norvegicus [Reaction:R-MMU-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Mus musculus
output	[Complex:R-HSA-5362413] C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-5362437] C-terminal Hh fragments are bound by lectins - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5362441
summation	[Summation:5362433] After binding to OS9/ERLEC1, the Hh C-terminal fragments are...

Referrals

(hasEvent)	[Pathway:R-HSA-5358346] Hedgehog ligand biogenesis
(precedingEvent)	[Reaction:R-HSA-5362412] SYVN1 ubiquitinates Hh C-terminal fragments