Reactome | Hedgehog ligand biogenesis

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Hedgehog ligand biogenesis Show undefined attributes

authored	[InstanceEdit:5357576] Rothfels, Karen, 2014-03-24
created	[InstanceEdit:5358347] Rothfels, Karen, 2014-03-27
dbId	5358346
displayName	Hedgehog ligand biogenesis
doi	10.3180/REACT_228111.1
edited	[InstanceEdit:5364056] D'Eustachio, Peter, 2014-04-19
eventOf	[Pathway:R-HSA-5358351] Signaling by Hedgehog - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-5362386] Glycosylation of Hh - Homo sapiens [Reaction:R-HSA-5358336] P4HB forms mixed disulphides with Hh precursors - Homo sapiens [Reaction:R-HSA-5358340] Autoproteolytic cleavage of Hh precursors - Homo sapiens [Reaction:R-HSA-5358343] HHAT palmitoylates Hh N-terminal fragment - Homo sapiens [BlackBoxEvent:R-HSA-5362549] Hh-Np traffics to the plasma membrane - Homo sapiens [Pathway:R-HSA-5362798] Release of Hh-Np from the secreting cell - Homo sapiens [Reaction:R-HSA-5362437] C-terminal Hh fragments are bound by lectins - Homo sapiens [Reaction:R-HSA-5362441] C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane - Homo sapiens [Reaction:R-HSA-5362412] SYVN1 ubiquitinates Hh C-terminal fragments - Homo sapiens [Reaction:R-HSA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-5362448] Hh C-terminal fragments are degraded by the proteasome - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358208] A review of hedgehog signaling in cranial bone development [LiteratureReference:3247720] Hedgehog morphogen: from secretion to reception [LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:208280] Cholesterol modification of hedgehog signaling proteins in animal development [LiteratureReference:5358231] Identification of a palmitic acid-modified form of human Sonic hedgehog [LiteratureReference:208337] Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal [LiteratureReference:5358222] Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix [LiteratureReference:5358214] Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand [LiteratureReference:5358244] The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins [LiteratureReference:5358238] Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates [LiteratureReference:216373] A freely diffusible form of Sonic hedgehog mediates long-range signalling [LiteratureReference:5358245] The mechanisms of Hedgehog signalling and its roles in development and disease [LiteratureReference:5483242] Nanoscale organization of hedgehog is essential for long-range signaling
modified	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
name	Hedgehog ligand biogenesis
orthologousEvent	[Pathway:R-SPO-5358346] Hedgehog ligand biogenesis - Schizosaccharomyces pombe [Pathway:R-DDI-5358346] Hedgehog ligand biogenesis - Dictyostelium discoideum [Pathway:R-CEL-5358346] Hedgehog ligand biogenesis - Caenorhabditis elegans [Pathway:R-DME-5358346] Hedgehog ligand biogenesis - Drosophila melanogaster [Pathway:R-GGA-5358346] Hedgehog ligand biogenesis - Gallus gallus [Pathway:R-XTR-5358346] Hedgehog ligand biogenesis - Xenopus tropicalis [Pathway:R-DRE-5358346] Hedgehog ligand biogenesis - Danio rerio [Pathway:R-SSC-5358346] Hedgehog ligand biogenesis - Sus scrofa [Pathway:R-BTA-5358346] Hedgehog ligand biogenesis - Bos taurus [Pathway:R-CFA-5358346] Hedgehog ligand biogenesis - Canis familiaris [Pathway:R-RNO-5358346] Hedgehog ligand biogenesis - Rattus norvegicus [Pathway:R-MMU-5358346] Hedgehog ligand biogenesis - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5358346
summation	[Summation:5358330] Mammalian genomes encode three Hedgehog ligands, Sonic Hedge...

Referrals

(hasEvent)	[Pathway:R-HSA-5358351] Signaling by Hedgehog
(normalPathway)	[Pathway:R-HSA-5387390] Hh mutants abrogate ligand secretion [Pathway:R-HSA-5658034] HHAT G278V doesn't palmitoylate Hh-Np [Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD

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