Reactome | Signaling by CTNNB1 phospho-site mutants

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Signaling by CTNNB1 phospho-site mutants Show undefined attributes

authored	[InstanceEdit:4839645] Rothfels, K, 2013-11-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839742] Rothfels, K, 2013-11-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	4839743
disease	[Disease:1500689] cancer
displayName	Signaling by CTNNB1 phospho-site mutants
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4791275] Signaling by WNT in cancer - Homo sapiens
figure	[Figure:9758322] /figures/ehld/R-HSA-4839743.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5358751] CTNNB1 S45 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5358752] CTNNB1 T41 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5358749] CTNNB1 S37 mutants aren't phosphorylated - Homo sapiens [Pathway:R-HSA-5358747] CTNNB1 S33 mutants aren't phosphorylated - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:5246621] Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC [LiteratureReference:5262590] Stabilization of beta-catenin by genetic defects in melanoma cell lines [LiteratureReference:5246631] Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta [LiteratureReference:5262587] Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus [LiteratureReference:5251485] Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis [LiteratureReference:3238089] The way Wnt works: Components and mechanism
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by CTNNB1 phospho-site mutants
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4839743
summation	[Summation:5262592] Mutations in exon 3 of the beta-catenin gene have been ident...
updateTrackers	[UpdateTracker:9785225] Update Tracker - [Pathway:4839743] Signaling by CTNNB1 phospho-site mutants - v52:[removeHasEvent, updateContainedPathway]

Referrals

(updatedInstance)	[UpdateTracker:9785225] Update Tracker - [Pathway:4839743] Signaling by CTNNB1 phospho-site mutants - v52:[removeHasEvent, updateContainedPathway]
(hasEvent)	[Pathway:R-HSA-4791275] Signaling by WNT in cancer