MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

Stable Identifier
R-HSA-5358512
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more
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The latent endonuclease activity of MLH1:PMS2 (MutLalpha) is activated by interaction with MSH2:MSH3 (MutSbeta) (Zhang et al. 2005, and inferred from activation of MLH1:PMS2 by MSH2:MSH6). MLH1:PMS2 makes a nick in the strand of DNA that will be repaired (Kadyrov et al. 2006).

Literature References
PubMed ID Title Journal Year
16873062 Endonucleolytic function of MutLalpha in human mismatch repair

Kadyrov, FA, Dzantiev, L, Constantin, N, Modrich, P

Cell 2006
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM

Cell 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endonuclease activity of MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm]
Physical Entity
MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm]
Activity
endonuclease activity (0004519)
Inferred From
MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)
Authored
May, B  (2014-03-28)
Reviewed
Edelbrock, MA  (2014-05-23)
Created
May, B  (2014-03-29)