Reactome | MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

Stable Identifier

R-HSA-5358512

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

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The latent endonuclease activity of MLH1:PMS2 (MutLalpha) is activated by interaction with MSH2:MSH3 (MutSbeta) (Zhang et al. 2005, and inferred from activation of MLH1:PMS2 by MSH2:MSH6). MLH1:PMS2 makes a nick in the strand of DNA that will be repaired (Kadyrov et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16143102	Reconstitution of 5'-directed human mismatch repair in a purified system Gao, Y, Zhang, Y, Li, GM, Yuan, F, Tian, K, Presnell, SR, Gu, L, Tomkinson, AE	Cell	2005
16873062	Endonucleolytic function of MutLalpha in human mismatch repair Dzantiev, L, Modrich, P, Kadyrov, FA, Constantin, N	Cell	2006