Reactome | Synthesis of diphthamide-EEF2

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Synthesis of diphthamide-EEF2 Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11079489
displayName	Synthesis of diphthamide-EEF2
eventOf	[Pathway:R-SPO-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25723] protein histidyl modification to diphthamide
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SPO-5358494] DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 - Schizosaccharomyces pombe [Reaction:R-SPO-5358484] DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 - Schizosaccharomyces pombe [Reaction:R-SPO-5358475] DPH6 ligates ammonium to diphthine-EEF2 - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-5358493] Synthesis of diphthamide-EEF2 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of diphthamide-EEF2
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-5358493
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(inferredTo)	[Pathway:R-HSA-5358493] Synthesis of diphthamide-EEF2