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TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
Stable Identifier
R-HSA-5357866
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20385093
Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation
Wang, Y
,
Wu, H
,
Zheng, C
,
Cheng, G
,
Kabaleeswaran, V
Mol. Cell
2010
Participants
components
BIRC2,3,4 [cytosol]
(Homo sapiens)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
(Homo sapiens)
Participates
as a member of
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
as an output of
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
as an input of
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
Inferred To
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Bos taurus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Danio rerio)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Mus musculus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Sus scrofa)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(Xenopus tropicalis)
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