PAK1-3 dimer disassociates

Stable Identifier
R-HSA-5357445
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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PAK1-3 dimer disassociates
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Binding of Rac1 increases p21 activated kinases 1-3 (PAK1-3) kinase activity and breaks the PAK dimer into monomers.

Literature References
PubMed ID Title Journal Year
11804587 Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

Parrini, MC, Lei, M, Mayer, BJ, Harrison, SC

Mol Cell 2002
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Orthologous Events
PAK1-3 dimer disassociates (Caenorhabditis elegans)
PAK1-3 dimer disassociates (Canis familiaris)
PAK1-3 dimer disassociates (Danio rerio)
PAK1-3 dimer disassociates (Drosophila melanogaster)
PAK1-3 dimer disassociates (Gallus gallus)
PAK1-3 dimer disassociates (Mus musculus)
PAK1-3 dimer disassociates (Rattus norvegicus)
PAK1-3 dimer disassociates (Sus scrofa)
PAK1-3 dimer disassociates (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2014-03-21)
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