Reactome | RNF43 frameshift mutants show enhanced WNT siganling

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RNF43 frameshift mutants show enhanced WNT siganling Show undefined attributes

authored	[InstanceEdit:5340172] Rothfels, K, 2014-03-11
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5340586] Rothfels, K, 2014-03-19
crossReference	[DatabaseIdentifier:12020779] Mondo:0009831
dbId	5340587
disease	[Disease:2328198] pancreatic cancer
displayName	RNF43 frameshift mutants show enhanced WNT siganling
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus	[EntityFunctionalStatus:5340585] loss_of_function of RNF43 mutants [plasma membrane]
eventOf	[Pathway:R-HSA-5340588] Signaling by RNF43 mutants - Homo sapiens
input	[Complex:R-HSA-4641176] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] [CandidateSet:R-HSA-5340583] RNF43 mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5333061] Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma [LiteratureReference:5340570] Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors [LiteratureReference:5340532] Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells [LiteratureReference:4641102] ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner [LiteratureReference:4641121] Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt [LiteratureReference:5340520] A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer [LiteratureReference:5340568] The Intestinal Wnt/TCF Signature
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNF43 frameshift mutants show enhanced WNT siganling
normalReaction	[Reaction:R-HSA-4641249] ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5340587
summation	[Summation:5340530] Frameshift and missense mutations have been identified in th...

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[Pathway:R-HSA-5340588] Signaling by RNF43 mutants

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