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Schema
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Pathway
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Entries
Signaling by RNF43 mutants
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authored
[InstanceEdit:5340172] Rothfels, K, 2014-03-11
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5340586] Rothfels, K, 2014-03-19
crossReference
[DatabaseIdentifier:12020745] Mondo:0004992
dbId
5340588
disease
[Disease:1500689] cancer
displayName
Signaling by RNF43 mutants
edited
[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf
[Pathway:R-HSA-4791275] Signaling by WNT in cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[FailedReaction:R-HSA-5340587] RNF43 frameshift mutants show enhanced WNT siganling - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2015-03-23
literatureReference
[LiteratureReference:4641121] Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
[LiteratureReference:5333061] Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
[LiteratureReference:4641102] ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
[LiteratureReference:5340570] Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name
Signaling by RNF43 mutants
normalPathway
[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5433076] Salahshor, S, 2014-05-12
[InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5340588
summation
[Summation:5340589] RNF43 and related protein ZNRF3 are E3 ubiquitin ligases tha...
updateTrackers
[UpdateTracker:9785384] Update Tracker - [Pathway:5340588] Signaling by RNF43 mutants - v52:[removeHasEvent]
Referrals
(updatedInstance)
[UpdateTracker:9785384] Update Tracker - [Pathway:5340588] Signaling by RNF43 mutants - v52:[removeHasEvent]
(hasEvent)
[Pathway:R-HSA-4791275] Signaling by WNT in cancer
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