Reactome | AXIN is phosphorylated in the destruction complex

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AXIN is phosphorylated in the destruction complex Show undefined attributes

catalystActivity	[CatalystActivity:10696733] protein serine/threonine kinase activity of AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10696735
displayName	AXIN is phosphorylated in the destruction complex
eventOf	[Pathway:R-XTR-195253] Degradation of beta-catenin by the destruction complex - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-195304] Association of beta-catenin with the destruction complex - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-5229343] AXIN is phosphorylated in the destruction complex - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-XTR-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AXIN is phosphorylated in the destruction complex
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-XTR-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5229343
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-XTR-195304] Association of beta-catenin with the destruction complex
(inferredTo)	[Reaction:R-HSA-5229343] AXIN is phosphorylated in the destruction complex

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