Reactome | PIAS1,4 SUMOylate CASP8AP2 with SUMO1

Schema > Reaction > Entries

PIAS1,4 SUMOylate CASP8AP2 with SUMO1 Show undefined attributes

catalystActivity	[CatalystActivity:10506061] SUMO transferase activity of PIAS1,4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10512286
displayName	PIAS1,4 SUMOylate CASP8AP2 with SUMO1
eventOf	[Pathway:R-SSC-3899300] SUMOylation of transcription cofactors - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-3927945] CASP8AP2 [nucleoplasm] [Complex:R-SSC-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PIAS1,4 SUMOylate CASP8AP2 with SUMO1 PIAS1,PIAS4 SUMOylate FLASH
output	[EntityWithAccessionedSequence:R-SSC-3927850] CASP8AP2 [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-SSC-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5228521
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-3899300] SUMOylation of transcription cofactors
(inferredTo)	[Reaction:R-HSA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1

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