DOCK180:ELMO exchanges GTP for GDP, activating RAC1

Stable Identifier
R-HSA-5218839
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex. RAC1 signaling facilitates VEGF-stimulated angiogenesis by regulating endothelial cell migration and vascular permeability. RAC1 promotes migration by stimulating actin reorganisation to form membrane ruffles and lamellipodia. RAC1 is also a critical component of endothelial NADPH oxidase promoting reactive oxygen species (ROS) prodcution. Specifically, VEGF acts through RAC1 to stimulate lamellipodia formation at the leading edge of polarized cells for directional migration, or chemotaxis. RAC1 induces vascular permeability in part by disrupting endothelial cell-cell junctions (Soga et al. 2001a, Soga et al. 2001b, Claesson-Welsh & Welsh, 2013).

Literature References
PubMed ID Title Journal Year
12134158 Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

Brugnera, E, Haney, L, Grimsley, C, Lu, M, Walk, SF, Tosello-Trampont, AC, Macara, IG, Madhani, H, Fink, GR, Ravichandran, KS

Nat Cell Biol 2002
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Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
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Orthologous Events
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