Reactome | POFUT2 transfers fucose to TSR domain-containing proteins

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POFUT2 transfers fucose to TSR domain-containing proteins Show undefined attributes

authored	[InstanceEdit:5172998] Jassal, B, 2013-11-25
catalystActivity	[CatalystActivity:5173083] peptide-O-fucosyltransferase activity of POFUT2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:5172998] Jassal, B, 2013-11-25
crossReference	[DatabaseIdentifier:9942381] RHEA:63645 [DatabaseIdentifier:9935471] RHEA:70492
dbId	5173192
displayName	POFUT2 transfers fucose to TSR domain-containing proteins
edited	[InstanceEdit:5172998] Jassal, B, 2013-11-25
eventOf	[Pathway:R-HSA-5173214] O-glycosylation of TSR domain-containing proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-5173005] B3GALTL transfers glucose to O-fucosyl-proteins - Homo sapiens
input	[SimpleEntity:R-ALL-1463452] GDP-Fuc [endoplasmic reticulum lumen] [CandidateSet:R-HSA-5173014] POFUT2 substrates [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5187397] Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation [LiteratureReference:5187417] C-mannosylation and O-fucosylation of the thrombospondin type 1 module [LiteratureReference:5187399] Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	POFUT2 transfers fucose to TSR domain-containing proteins
orthologousEvent	[Reaction:R-PFA-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Plasmodium falciparum [Reaction:R-CEL-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Caenorhabditis elegans [Reaction:R-DME-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Drosophila melanogaster [Reaction:R-GGA-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Gallus gallus [Reaction:R-XTR-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Xenopus tropicalis [Reaction:R-DRE-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Danio rerio [Reaction:R-SSC-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Sus scrofa [Reaction:R-BTA-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Bos taurus [Reaction:R-CFA-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Canis familiaris [Reaction:R-RNO-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Rattus norvegicus [Reaction:R-MMU-5173192] POFUT2 transfers fucose to TSR domain-containing proteins - Mus musculus
output	[SimpleEntity:R-ALL-9942379] GDP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [CandidateSet:R-HSA-5173164] O-fuc-proteins [endoplasmic reticulum lumen]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5260211] D'Eustachio, Peter, 2014-02-07 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08 [InstanceEdit:9970594] D'Eustachio, Peter, 2025-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5173192
summation	[Summation:5187430] The O-fucosylation of proteins containing thrombospondin typ...
updateTrackers	[UpdateTracker:9953669] Update Tracker - [Reaction:5173192] POFUT2 transfers fucose to TSR domain-containing proteins - v93:[removeInput, removeOutput] [UpdateTracker:9971948] Update Tracker - [Reaction:5173192] POFUT2 transfers fucose to TSR domain-containing proteins - v95:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9953669] Update Tracker - [Reaction:5173192] POFUT2 transfers fucose to TSR domain-containing proteins - v93:[removeInput, removeOutput] [UpdateTracker:9971948] Update Tracker - [Reaction:5173192] POFUT2 transfers fucose to TSR domain-containing proteins - v95:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-5173214] O-glycosylation of TSR domain-containing proteins
(precedingEvent)	[Reaction:R-HSA-5173005] B3GALTL transfers glucose to O-fucosyl-proteins

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