Reactome | POFUT2 transfers fucose to TSR domain-containing proteins

POFUT2 transfers fucose to TSR domain-containing proteins

Stable Identifier

R-HSA-5173192

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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POFUT2 transfers fucose to TSR domain-containing proteins

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The O-fucosylation of proteins containing thrombospondin type 1 repeat (TSR1) domains is carried out by protein fucosyltransferase 2 (POFUT2). Only POFUT2 recognises the consensus sequence CSXS/TCG found in TSR1 domains and the fucosyl residue is attached to the hydroxyl group of conserved serine (S) or threonine (T) residues within the consensus sequence (Chen et al. 2012). The modification was first demonstrated on thrombospondin 1 (THBS1, TSP1), found in platelets and the ECM (Hofsteenge et al. 2001, Luo et al. 2006). In humans, there are more than 60 of these TSR1 domain-containing proteins. Only the proteins with similarity to experimentally confirmed ones are listed as candidates.

Literature References

PubMed ID	Title	Journal	Year
22588082	Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation Hofsteenge, J, Gut, H, Hess, D, Klein, D, Chen, CI, Keusch, JJ	EMBO J.	2012
16464858	Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats Haltiwanger, RS, Nita-Lazar, A, Luo, Y	J. Biol. Chem.	2006
11067851	C-mannosylation and O-fucosylation of the thrombospondin type 1 module Huwiler, KG, Mosher, DF, Hofsteenge, J, Lawler, J, Hess, D, Macek, B, Peter-Katalinic, J	J. Biol. Chem.	2001