Reactome | WNT5A binds FZD4

Schema > Reaction > Entries

WNT5A binds FZD4 Show undefined attributes

authored	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5099902] Rothfels, K, 2013-11-13
dbId	5099899
displayName	WNT5A binds FZD4
edited	[InstanceEdit:5144530] Matthews, L, 2013-11-15
eventOf	[Pathway:R-HSA-5099900] WNT5A-dependent internalization of FZD4 - Homo sapiens
followingEvent	[Reaction:R-HSA-5138441] WNT5A-FZD4 recruits DVL2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-443956] FZD4 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5138423] Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WNT5A binds FZD4
orthologousEvent	[Reaction:R-CEL-5099899] WNT5A binds FZD4 - Caenorhabditis elegans [Reaction:R-GGA-5099899] WNT5A binds FZD4 - Gallus gallus [Reaction:R-XTR-5099899] WNT5A binds FZD4 - Xenopus tropicalis [Reaction:R-SSC-5099899] WNT5A binds FZD4 - Sus scrofa [Reaction:R-BTA-5099899] WNT5A binds FZD4 - Bos taurus [Reaction:R-CFA-5099899] WNT5A binds FZD4 - Canis familiaris [Reaction:R-RNO-5099899] WNT5A binds FZD4 - Rattus norvegicus [Reaction:R-MMU-5099899] WNT5A binds FZD4 - Mus musculus
output	[Complex:R-HSA-5099901] N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5099899
summation	[Summation:5138463] WNT5A stimulation of FZD4-expressing HEK293 cells promotes i...

Referrals

(hasEvent)	[Pathway:R-HSA-5099900] WNT5A-dependent internalization of FZD4
(precedingEvent)	[Reaction:R-HSA-5138441] WNT5A-FZD4 recruits DVL2