WNT5A binds FZD4

Stable Identifier
R-HSA-5099899
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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WNT5A binds FZD4
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WNT5A stimulation of FZD4-expressing HEK293 cells promotes internalization of the receptor, suggesting a receptor-ligand interaction (Chen et al, 2003).
Literature References
PubMed ID Title Journal Year
12958364 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Chen, W, Ahn, S, Caron, MG, Barak, LS, Brown, J, Hu, LA, Lefkowitz, RJ, Nusse, R, Miller, WE, ten Berge, D

Science 2003
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Orthologous Events
WNT5A binds FZD4 (Bos taurus)
WNT5A binds FZD4 (Caenorhabditis elegans)
WNT5A binds FZD4 (Canis familiaris)
WNT5A binds FZD4 (Gallus gallus)
WNT5A binds FZD4 (Mus musculus)
WNT5A binds FZD4 (Rattus norvegicus)
WNT5A binds FZD4 (Sus scrofa)
WNT5A binds FZD4 (Xenopus tropicalis)
Authored
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-11-13)
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