Reactome | WNT5A binds FZD4

Schema > Reaction > Entries

WNT5A binds FZD4 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10695603
displayName	WNT5A binds FZD4
eventOf	[Pathway:R-XTR-5099900] WNT5A-dependent internalization of FZD4 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-5138441] WNT5A-FZD4 recruits DVL2 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-5099899] WNT5A binds FZD4 - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-443956] fzd4 [plasma membrane] [EntityWithAccessionedSequence:R-XTR-3247777] wnt5a [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	WNT5A binds FZD4
output	[Complex:R-XTR-5099901] N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane]
precedingEvent	[Reaction:R-XTR-3247843] secretion of WNT ligands - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5099899
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5099900] WNT5A-dependent internalization of FZD4
(precedingEvent)	[Reaction:R-XTR-5138441] WNT5A-FZD4 recruits DVL2
(inferredTo)	[Reaction:R-HSA-5099899] WNT5A binds FZD4