Reactome | p85-containing Class 1A PI3Ks [cytosol]

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p85-containing Class 1A PI3Ks [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-508238] IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] - Homo sapiens [Complex:R-HSA-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] - Homo sapiens [Complex:R-HSA-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens [Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens [Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens [Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens [BlackBoxEvent:R-HSA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Homo sapiens [Reaction:R-HSA-914182] 14-3-3 zeta binding allows recruitment of PI3K - Homo sapiens [Reaction:R-HSA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Homo sapiens
created	[InstanceEdit:508240] Jupe, S, 2010-02-11
dbId	508248
displayName	p85-containing Class 1A PI3Ks [cytosol]
hasMember	[Complex:R-HSA-198379] PI3K alpha [cytosol] - Homo sapiens [Complex:R-HSA-437110] PI3K beta [cytosol] - Homo sapiens [Complex:R-HSA-508241] PI3K delta [cytosol] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-508248] p85-containing Class 1A PI3Ks [cytosol] - Mus musculus [DefinedSet:R-RNO-508248] p85-containing Class 1A PI3Ks [cytosol] - Rattus norvegicus [DefinedSet:R-CFA-508248] p85-containing Class 1A PI3Ks [cytosol] - Canis familiaris [DefinedSet:R-BTA-508248] p85-containing Class 1A PI3Ks [cytosol] - Bos taurus [DefinedSet:R-SSC-508248] p85-containing Class 1A PI3Ks [cytosol] - Sus scrofa [DefinedSet:R-DRE-508248] p85-containing Class 1A PI3Ks [cytosol] - Danio rerio [DefinedSet:R-XTR-508248] p85-containing Class 1A PI3Ks [cytosol] - Xenopus tropicalis [DefinedSet:R-GGA-508248] p85-containing Class 1A PI3Ks [cytosol] - Gallus gallus [DefinedSet:R-DME-508248] p85-containing Class 1A PI3Ks [cytosol] - Drosophila melanogaster [Complex:R-CEL-74693] PI3K [cytosol] - Caenorhabditis elegans
maxDepth	4
modified	[InstanceEdit:912661] Jupe, S, 2010-07-12
name	p85-containing Class 1A PI3Ks
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-508248
summation	[Summation:508237] This set represents Class 1A PI3Ks including all three genes...
updateTrackers	[UpdateTracker:9875360] Update Tracker - [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] - v44:[updateContainedMemberOrCandidate]

Referrals

(updatedInstance)	[UpdateTracker:9875360] Update Tracker - [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] - v44:[updateContainedMemberOrCandidate]
(hasComponent)	[Complex:R-HSA-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-HSA-914177] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-HSA-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-HSA-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-HSA-508238] IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-HSA-926773] High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-HSA-912532] IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-HSA-926774] High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane]
(input)	[BlackBoxEvent:R-HSA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K [Reaction:R-HSA-914182] 14-3-3 zeta binding allows recruitment of PI3K [Reaction:R-HSA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases

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