Reactome | p85-containing Class 1A PI3Ks [cytosol]

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p85-containing Class 1A PI3Ks [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-508238] IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] - Mus musculus [Complex:R-MMU-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] - Mus musculus [Complex:R-MMU-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] - Mus musculus
consumedByEvent	[Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Mus musculus [Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Mus musculus [Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Mus musculus [Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Mus musculus [BlackBoxEvent:R-MMU-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Mus musculus [Reaction:R-MMU-914182] 14-3-3 zeta binding allows recruitment of PI3K - Mus musculus [Reaction:R-MMU-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10020126
displayName	p85-containing Class 1A PI3Ks [cytosol]
hasMember	[Complex:R-MMU-198379] PI3K alpha [cytosol] - Mus musculus [Complex:R-MMU-437110] PI3K beta [cytosol] - Mus musculus [Complex:R-MMU-508241] PI3K delta [cytosol] - Mus musculus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-508248] p85-containing Class 1A PI3Ks [cytosol] - Homo sapiens
maxDepth	4
name	p85-containing Class 1A PI3Ks
schemaClass	DefinedSet
species	[Species:48892] Mus musculus
stId	R-MMU-508248

Referrals

(input)	[BlackBoxEvent:R-MMU-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K [Reaction:R-MMU-914182] 14-3-3 zeta binding allows recruitment of PI3K [Reaction:R-MMU-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases
(hasComponent)	[Complex:R-MMU-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-MMU-914177] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-MMU-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-MMU-508238] IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-MMU-926773] High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-MMU-912532] IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-MMU-926774] High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane]
(inferredTo)	[DefinedSet:R-HSA-508248] p85-containing Class 1A PI3Ks [cytosol]

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