Reactome | p85-containing Class 1A PI3Ks [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DRE-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] - Danio rerio [Complex:R-DRE-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] - Danio rerio
consumedByEvent	[BlackBoxEvent:R-DRE-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Danio rerio [Reaction:R-DRE-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10588439
displayName	p85-containing Class 1A PI3Ks [cytosol]
hasMember	[Complex:R-DRE-198379] PI3K alpha [cytosol] - Danio rerio [Complex:R-DRE-437110] PI3K beta [cytosol] - Danio rerio [Complex:R-DRE-508241] PI3K delta [cytosol] - Danio rerio
inDisease	false
inferredFrom	[DefinedSet:R-HSA-508248] p85-containing Class 1A PI3Ks [cytosol] - Homo sapiens
maxDepth	4
name	p85-containing Class 1A PI3Ks
schemaClass	DefinedSet
species	[Species:68323] Danio rerio
stId	R-DRE-508248

(input)	[BlackBoxEvent:R-DRE-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K [Reaction:R-DRE-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
(hasComponent)	[Complex:R-DRE-8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Complex:R-DRE-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-DRE-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol]
(inferredTo)	[DefinedSet:R-HSA-508248] p85-containing Class 1A PI3Ks [cytosol]