Reactome | p62:MEKK3 binds to TRAF6

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p62:MEKK3 binds to TRAF6 Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:507710] Jupe, S, 2010-02-08
dbId	507719
displayName	p62:MEKK3 binds to TRAF6
edited	[InstanceEdit:744683] Jupe, S, 2010-05-17
eventOf	[Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
input	[Complex:R-HSA-507714] MAP3K3:SQSTM1 [cytosol] [EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:507712] PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p62:MEKK3 binds to TRAF6
orthologousEvent	[Reaction:R-BTA-507719] p62:MEKK3 binds to TRAF6 - Bos taurus [Reaction:R-GGA-507719] p62:MEKK3 binds to TRAF6 - Gallus gallus [Reaction:R-DRE-507719] p62:MEKK3 binds to TRAF6 - Danio rerio [Reaction:R-SSC-507719] p62:MEKK3 binds to TRAF6 - Sus scrofa [Reaction:R-CFA-507719] p62:MEKK3 binds to TRAF6 - Canis familiaris [Reaction:R-RNO-507719] p62:MEKK3 binds to TRAF6 - Rattus norvegicus [Reaction:R-MMU-507719] p62:MEKK3 binds to TRAF6 - Mus musculus
output	[Complex:R-HSA-507716] MAP3K3:SQSTM1:TRAF6 [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-507738] Negative regulation by 'IL1B(117-269) [cytosol]'
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-507719
summation	[Summation:507726] p62, MEKK3 and TRAF6 co-localize in cytoplasmic aggregates t...

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[Pathway:R-HSA-9020702] Interleukin-1 signaling

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