Reactome | p62:MEKK3 binds to TRAF6

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10020027
displayName	p62:MEKK3 binds to TRAF6
eventOf	[Pathway:R-MMU-9020702] Interleukin-1 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-507719] p62:MEKK3 binds to TRAF6 - Homo sapiens
input	[Complex:R-MMU-507714] MAP3K3:SQSTM1 [cytosol] [EntityWithAccessionedSequence:R-MMU-166366] Traf6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p62:MEKK3 binds to TRAF6
output	[Complex:R-MMU-507716] MAP3K3:SQSTM1:TRAF6 [cytosol]
regulatedBy	[NegativeRegulation:10020028] Negative regulation by 'IL1B(117-269) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-507719
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-9020702] Interleukin-1 signaling
(inferredTo)	[Reaction:R-HSA-507719] p62:MEKK3 binds to TRAF6

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