LIN28 binds POU5F1 (OCT4) mRNA

Stable Identifier
R-HSA-500366
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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LIN28 binds POU5F1 (OCT4) mRNA
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LIN28 binds the R2 region of the POU5F1 (OCT4) mRNA and increases translation of a luciferase reporter mRNA containing the binding site (Qiu et al. 2009, Lei et al. 2012). Reduction of LIN28 levels in embryonic stem cells causes a reduction in POU5F1 protein (Qiu et al. 2009).

Literature References
PubMed ID Title Journal Year
22210884 Determinants of mRNA recognition and translation regulation by Lin28

Lei, XX, Xu, J, Ma, W, Qiao, C, Newman, MA, Hammond, SM, Huang, Y

Nucleic Acids Res. 2012
19966271 Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

Qiu, C, Ma, Y, Wang, J, Peng, S, Huang, Y

Nucleic Acids Res 2009
Participants
Input
Output
Participant Of
hasEvent
Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-02-03)