LIN28 binds POU5F1 (OCT4) mRNA

Stable Identifier
R-HSA-500366
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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LIN28 binds POU5F1 (OCT4) mRNA
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LIN28 binds the R2 region of the POU5F1 (OCT4) mRNA and increases translation of a luciferase reporter mRNA containing the binding site (Qiu et al. 2009, Lei et al. 2012). Reduction of LIN28 levels in embryonic stem cells causes a reduction in POU5F1 protein (Qiu et al. 2009).
Literature References
PubMed ID Title Journal Year
19966271 Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

Peng, S, Huang, Y, Qiu, C, Wang, J, Ma, Y

Nucleic Acids Res 2009
22210884 Determinants of mRNA recognition and translation regulation by Lin28

Qiao, C, Lei, XX, Hammond, SM, Huang, Y, Newman, MA, Ma, W, Xu, J

Nucleic Acids Res. 2012
Participants
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Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-02-03)
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