LIN28 binds the R2 region of the POU5F1 (OCT4) mRNA and increases translation of a luciferase reporter mRNA containing the binding site (Qiu et al. 2009, Lei et al. 2012). Reduction of LIN28 levels in embryonic stem cells causes a reduction in POU5F1 protein (Qiu et al. 2009).
Lei, XX, Xu, J, Ma, W, Qiao, C, Newman, MA, Hammond, SM, Huang, Y
Qiu, C, Ma, Y, Wang, J, Peng, S, Huang, Y
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