Reactome | SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

Stable Identifier

R-HSA-4827382

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate Me2K10-histone H3 (H3K9), SUV39H1, SUV39H2, SETDB1, SETDB2 methylate Me2K10-histone H3

ReviewStatus

5/5

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SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

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SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selectively methylate lysine-10 of histone H3 (H3K9) (Rea et al. 2000, Rice et al. 2003, Falandry et al. 2010). Their predominant activity is conversion of dimethylated H3K9 to trimethylated H3K9 (Peters et al. 2003, Rice et al. 2003, Chin et al. 2006). SETDB1 (ESET, KMT1E) also predominantly methylates dimethylated H3K9 (Schultz et al. 2002), most effectively when complexed with ATF7IP (MCAF, hAM) (Wang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14690610	Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains Shinkai, Y, Shabanowitz, J, Hunt, DF, Briggs, SD, Allis, CD, Ueberheide, B, Rice, JC, Barber, CM	Mol Cell	2003
16519522	Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis Pradhan, S, Jacobsen, SE, Chin, HG, Patnaik, D, Estève, PO	Biochemistry	2006
11959841	SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins Schultz, DC, Ayyanathan, K, Maul, GG, Rauscher, FJ, Negorev, D	Genes Dev.	2002
10949293	Regulation of chromatin structure by site-specific histone H3 methyltransferases Schmid, M, Sun, ZW, Jenuwein, T, Eisenhaber, F, Mechtler, K, Rea, S, O'Carroll, D, Opravil, S, Ponting, CP, Strahl, BD, Allis, CD	Nature	2000