SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

Stable Identifier
Reaction [transition]
Homo sapiens
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate Me2K10-histone H3 (H3K9), SUV39H1, SUV39H2, SETDB1, SETDB2 methylate Me2K10-histone H3
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SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selectively methylate lysine-10 of histone H3 (H3K9) (Rea et al. 2000, Rice et al. 2003, Falandry et al. 2010). Their predominant activity is conversion of dimethylated H3K9 to trimethylated H3K9 (Peters et al. 2003, Rice et al. 2003, Chin et al. 2006). SETDB1 (ESET, KMT1E) also predominantly methylates dimethylated H3K9 (Schultz et al. 2002), most effectively when complexed with ATF7IP (MCAF, hAM) (Wang et al. 2003).

Literature References
PubMed ID Title Journal Year
14690610 Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

Shinkai, Y, Shabanowitz, J, Hunt, DF, Briggs, SD, Allis, CD, Ueberheide, B, Rice, JC, Barber, CM

Mol Cell 2003
16519522 Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis

Pradhan, S, Jacobsen, SE, Chin, HG, Patnaik, D, Estève, PO

Biochemistry 2006
11959841 SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Schultz, DC, Ayyanathan, K, Maul, GG, Rauscher, FJ, Negorev, D

Genes Dev. 2002
10949293 Regulation of chromatin structure by site-specific histone H3 methyltransferases

Schmid, M, Sun, ZW, Jenuwein, T, Eisenhaber, F, Mechtler, K, Rea, S, O'Carroll, D, Opravil, S, Ponting, CP, Strahl, BD, Allis, CD

Nature 2000
Catalyst Activity

histone H3 methyltransferase activity of SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm]

This event is regulated