Reactome | SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selec...

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SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selec... Show undefined attributes

created	[InstanceEdit:4827380] Jupe, S, 2013-10-29
dbId	4827378
displayName	SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selec...
literatureReference	[LiteratureReference:3301877] Regulation of chromatin structure by site-specific histone H3 methyltransferases [LiteratureReference:427757] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains [LiteratureReference:5634730] Partitioning and plasticity of repressive histone methylation states in mammalian chromatin [LiteratureReference:427759] Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis [LiteratureReference:5634749] CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation [LiteratureReference:5173305] SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins [LiteratureReference:3301890] mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression
modified	[InstanceEdit:5674398] Jupe, Steve, 2015-02-12
schemaClass	Summation
text	SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selectively methylate lysine-10 of histone H3 (H3K9) (Rea et al. 2000, Rice et al. 2003, Falandry et al. 2010). Their predominant activity is conversion of dimethylated H3K9 to trimethylated H3K9 (Peters et al. 2003, Rice et al. 2003, Chin et al. 2006). SETDB1 (ESET, KMT1E) also predominantly methylates dimethylated H3K9 (Schultz et al. 2002), most effectively when complexed with ATF7IP (MCAF, hAM) (Wang et al. 2003).

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(summation)

[Reaction:R-HSA-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

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