Ubiquitinated DVL1 is degraded by the proteasome

Stable Identifier
R-HSA-4641260
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ubiquitinated DVL1 is degraded by the proteasome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After ubiquitination by HECW1, DVL1 is degraded by the proteasome.

Literature References
PubMed ID Title Journal Year
14684739 NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1

Miyazaki, K, Fujita, T, Ozaki, T, Kato, C, Kurose, Y, Sakamoto, M, Kato, S, Goto, T, Itoyama, Y, Aoki, M, Nakagawara, A

J. Biol. Chem. 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
26S proteasome [cytosol]
Activity
endopeptidase activity (0004175)
Orthologous Events
Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)
Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
Ubiquitinated DVL1 is degraded by the proteasome (Danio rerio)
Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)
Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)
Ubiquitinated DVL1 is degraded by the proteasome (Rattus norvegicus)
Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)
Ubiquitinated DVL1 is degraded by the proteasome (Xenopus tropicalis)
Authored
Rothfels, K  (2013-09-23)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-09-28)
Cite Us!