Reactome | Degradation of AXIN

Schema > Pathway > Entries

Degradation of AXIN Show undefined attributes

authored	[InstanceEdit:3772170] Rothfels, K, 2013-06-24
created	[InstanceEdit:4641255] Rothfels, K, 2013-09-27
dbId	4641257
displayName	Degradation of AXIN
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02 [InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:529181] positive regulation of canonical Wnt signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3640862] Tankyrase binds AXIN - Homo sapiens [Reaction:R-HSA-3640858] Tankyrase ADP-ribosylates AXIN - Homo sapiens [Reaction:R-HSA-3640844] RNF146 binds RibC-AXIN:TNKS complex - Homo sapiens [Reaction:R-HSA-3640861] RNF146 ubiquitinates ADP-ribosylated AXIN - Homo sapiens [BlackBoxEvent:R-HSA-3640874] Ub-RibC-AXIN is degraded by the proteasome - Homo sapiens [Reaction:R-HSA-4641134] SMURF2 binds AXIN - Homo sapiens [Reaction:R-HSA-4641129] AXIN is ubiquitinated by SMURF2 - Homo sapiens [BlackBoxEvent:R-HSA-4641256] Ubiquitinated AXIN is degraded by the proteasome - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208277] The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway [LiteratureReference:4641109] Wnt signalling pathway parameters for mammalian cells [LiteratureReference:3640803] Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling [LiteratureReference:3640792] RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling [LiteratureReference:4641105] The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Degradation of AXIN
orthologousEvent	[Pathway:R-CEL-4641257] Degradation of AXIN - Caenorhabditis elegans [Pathway:R-DME-4641257] Degradation of AXIN - Drosophila melanogaster [Pathway:R-GGA-4641257] Degradation of AXIN - Gallus gallus [Pathway:R-XTR-4641257] Degradation of AXIN - Xenopus tropicalis [Pathway:R-DRE-4641257] Degradation of AXIN - Danio rerio [Pathway:R-SSC-4641257] Degradation of AXIN - Sus scrofa [Pathway:R-BTA-4641257] Degradation of AXIN - Bos taurus [Pathway:R-CFA-4641257] Degradation of AXIN - Canis familiaris [Pathway:R-RNO-4641257] Degradation of AXIN - Rattus norvegicus [Pathway:R-MMU-4641257] Degradation of AXIN - Mus musculus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4641257
summation	[Summation:4641125] AXIN is present in low concentrations in the cell and is con...

Referrals

(hasEvent)

[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT

Cite Us!