Reactome | Ub-RibC-AXIN is degraded by the proteasome

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3640875] Rothfels, K, 2013-05-29
dbId	3640874
displayName	Ub-RibC-AXIN is degraded by the proteasome
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641257] Degradation of AXIN - Homo sapiens
input	[Complex:R-HSA-3640854] Ub-RibC-AXIN:TNKS:RNF146 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3640792] RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling [LiteratureReference:3640796] Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling [LiteratureReference:3640803] Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Ub-RibC-AXIN is degraded by the proteasome
orthologousEvent	[BlackBoxEvent:R-CEL-3640874] Ub-RibC-AXIN is degraded by the proteasome - Caenorhabditis elegans [BlackBoxEvent:R-DME-3640874] Ub-RibC-AXIN is degraded by the proteasome - Drosophila melanogaster [BlackBoxEvent:R-GGA-3640874] Ub-RibC-AXIN is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-BTA-3640874] Ub-RibC-AXIN is degraded by the proteasome - Bos taurus [BlackBoxEvent:R-CFA-3640874] Ub-RibC-AXIN is degraded by the proteasome - Canis familiaris [BlackBoxEvent:R-RNO-3640874] Ub-RibC-AXIN is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-MMU-3640874] Ub-RibC-AXIN is degraded by the proteasome - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3640827] RNF146 [cytosol] [DefinedSet:R-HSA-3640826] TNKS1/2 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-3640861] RNF146 ubiquitinates ADP-ribosylated AXIN - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3640874
summation	[Summation:3640831] In the presence of the proteasome inhibitor MG132, polyubiqu...

Ub-RibC-AXIN is degraded by the proteasome Show undefined attributes

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