Reactome | Ubiquitinated AXIN is degraded by the proteasome

Schema > BlackBoxEvent > Entries

Ubiquitinated AXIN is degraded by the proteasome Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4641255] Rothfels, K, 2013-09-27
dbId	4641256
displayName	Ubiquitinated AXIN is degraded by the proteasome
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641257] Degradation of AXIN - Homo sapiens
input	[Complex:R-HSA-4641139] ub-AXIN:SMURF2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4641105] The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Ubiquitinated AXIN is degraded by the proteasome
orthologousEvent	[BlackBoxEvent:R-DME-4641256] Ubiquitinated AXIN is degraded by the proteasome - Drosophila melanogaster [BlackBoxEvent:R-GGA-4641256] Ubiquitinated AXIN is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-XTR-4641256] Ubiquitinated AXIN is degraded by the proteasome - Xenopus tropicalis [BlackBoxEvent:R-DRE-4641256] Ubiquitinated AXIN is degraded by the proteasome - Danio rerio [BlackBoxEvent:R-SSC-4641256] Ubiquitinated AXIN is degraded by the proteasome - Sus scrofa [BlackBoxEvent:R-BTA-4641256] Ubiquitinated AXIN is degraded by the proteasome - Bos taurus [BlackBoxEvent:R-CFA-4641256] Ubiquitinated AXIN is degraded by the proteasome - Canis familiaris [BlackBoxEvent:R-RNO-4641256] Ubiquitinated AXIN is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-MMU-4641256] Ubiquitinated AXIN is degraded by the proteasome - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-173537] SMURF2 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-4641129] AXIN is ubiquitinated by SMURF2 - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-4641256
summation	[Summation:4641142] After ubiquitination by SMURF2, AXIN is degraded by the prot...

Referrals

(hasEvent)

[Pathway:R-HSA-4641257] Degradation of AXIN

(precedingEvent)

[NegativePrecedingEvent:9965546] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965506] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965527] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965521] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965512] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965509] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965511] Futile Cycle: Ubiquitinated AXIN is degraded by the proteasome