WNT5A binds ROR2 and VANGL2 to promote PCP in mouse limb buds. A complex of WNT5A:ROR2:VANGL2 is established along the WNT5A gradient in chondrocytes and regulates VANGL2 phosphorylation. This initiates the establishment of PCP asymmetry in these cells, a hallmark of the PCP pathway (Gao et al, 2011). ROR2 has been shown to function as a receptor or co-receptor for WNT5A in other mammalian systems (Oishi et al, 2003; Mikels and Nusse, 2006; reviewed in Minami et al, 2010), and WNT5A:ROR2 signaling can also negatively regulate canonical beta-catenin-dependent transcription as assessed by reporter gene activity (Mikels and Nusse, 2006; Li et al, 2008).
Song, H, Yang, Y, Garrett, L, Robinson, J, Economides, AN, Minami, Y, Bishop, K, English, MA, Gao, B, Sood, R, Andre, P, Elliot, G
Oishi, I, Minami, Y, Endo, M, Nishita, M
Villosis, MF, Li, J, Sasaki, T, Xing, Y, Minoo, P, Minami, Y, Hu, L, Li, C, Chen, H, Nishita, M
Shibuya, H, Oishi, I, Minami, Y, Kani, S, Ohkawara, B, Koshida, I, Suzuki, K, Yamada, G, Mundlos, S, Suzuki, H, Takada, R, Onishi, N, Takada, S, Schwabe, GC
Mikels, AJ, Nusse, R
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