WNT5A binds ROR2 and VANGL2 to promote PCP in mouse limb buds. A complex of WNT5A:ROR2:VANGL2 is established along the WNT5A gradient in chondrocytes and regulates VANGL2 phosphorylation. This initiates the establishment of PCP asymmetry in these cells, a hallmark of the PCP pathway (Gao et al, 2011). ROR2 has been shown to function as a receptor or co-receptor for WNT5A in other mammalian systems (Oishi et al, 2003; Mikels and Nusse, 2006; reviewed in Minami et al, 2010), and WNT5A:ROR2 signaling can also negatively regulate canonical beta-catenin-dependent transcription as assessed by reporter gene activity (Mikels and Nusse, 2006; Li et al, 2008).
Minami, Y, Oishi, I, Endo, M, Nishita, M
Gao, B, Song, H, Bishop, K, Elliot, G, Garrett, L, English, MA, Andre, P, Robinson, J, Sood, R, Minami, Y, Economides, AN, Yang, Y
Li, C, Chen, H, Hu, L, Xing, Y, Sasaki, T, Villosis, MF, Li, J, Nishita, M, Minami, Y, Minoo, P
Oishi, I, Suzuki, H, Onishi, N, Takada, R, Kani, S, Ohkawara, B, Koshida, I, Suzuki, K, Yamada, G, Schwabe, GC, Mundlos, S, Shibuya, H, Takada, S, Minami, Y
Mikels, AJ, Nusse, R
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