WNT5A binds ROR2 and VANGL2

Stable Identifier
R-HSA-4551571
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
WNT5A binds ROR2 and VANGL2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WNT5A binds ROR2 and VANGL2 to promote PCP in mouse limb buds. A complex of WNT5A:ROR2:VANGL2 is established along the WNT5A gradient in chondrocytes and regulates VANGL2 phosphorylation. This initiates the establishment of PCP asymmetry in these cells, a hallmark of the PCP pathway (Gao et al, 2011). ROR2 has been shown to function as a receptor or co-receptor for WNT5A in other mammalian systems (Oishi et al, 2003; Mikels and Nusse, 2006; reviewed in Minami et al, 2010), and WNT5A:ROR2 signaling can also negatively regulate canonical beta-catenin-dependent transcription as assessed by reporter gene activity (Mikels and Nusse, 2006; Li et al, 2008).

Literature References
PubMed ID Title Journal Year
19530173 Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases

Minami, Y, Oishi, I, Endo, M, Nishita, M

Dev. Dyn. 2010
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Gao, B, Song, H, Bishop, K, Elliot, G, Garrett, L, English, MA, Andre, P, Robinson, J, Sood, R, Minami, Y, Economides, AN, Yang, Y

Dev. Cell 2011
18215320 Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2

Li, C, Chen, H, Hu, L, Xing, Y, Sasaki, T, Villosis, MF, Li, J, Nishita, M, Minami, Y, Minoo, P

BMC Mol. Biol. 2008
12839624 The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

Oishi, I, Suzuki, H, Onishi, N, Takada, R, Kani, S, Ohkawara, B, Koshida, I, Suzuki, K, Yamada, G, Schwabe, GC, Mundlos, S, Shibuya, H, Takada, S, Minami, Y

Genes Cells 2003
16602827 Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

Mikels, AJ, Nusse, R

PLoS Biol 2006
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Wnt5a binds Ror2 and Vangl2 (Mus musculus)
Authored
Rothfels, K  (2013-09-12)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-14)