Reactome | Expression of TBXT (T, Brachyury) in the primitive streak

Schema > BlackBoxEvent > Entries

Expression of TBXT (T, Brachyury) in the primitive streak Show undefined attributes

authored	[InstanceEdit:1013049] May, B, 2010-11-12
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:452990] May, B, 2010-01-15
dbId	452331
displayName	Expression of TBXT (T, Brachyury) in the primitive streak
edited	[InstanceEdit:1013049] May, B, 2010-11-12
eventOf	[Pathway:R-HSA-9754189] Germ layer formation at gastrulation - Homo sapiens
followingEvent	[Reaction:R-HSA-9733781] EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene - Homo sapiens [Reaction:R-HSA-9756671] EOMES and TBXT bind the NANOG gene - Homo sapiens [Reaction:R-HSA-9756670] EOMES and TBXT bind the POU5F1 (OCT4) gene - Homo sapiens [Reaction:R-HSA-9756661] EOMES and TBXT bind the SOX2 gene - Homo sapiens [BlackBoxEvent:R-HSA-9796300] Expression of NOTO in axial mesoderm - Homo sapiens [BlackBoxEvent:R-HSA-9793921] Expression of DLL1 in paraxial mesoderm - Homo sapiens [BlackBoxEvent:R-HSA-9793383] Expression of TBX6 in paraxial mesoderm - Homo sapiens [Reaction:R-HSA-9756666] EOMES and TBXT (T, Brachyury) bind the SNAI1 gene - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9754300] Expression of T (Tbxt) in the primitive streak - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-2888965] TBXT gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:452679] Robust generation of hemangioblastic progenitors from human embryonic stem cells [LiteratureReference:452664] Analysis of the temporal and concentration-dependent effects of BMP-4, VEGF, and TPO on development of embryonic stem cell-derived mesoderm and blood progenitors in a defined, serum-free media [LiteratureReference:452440] Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells [LiteratureReference:9754295] TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:9757060] ?-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of TBXT (T, Brachyury) in the primitive streak
output	[EntityWithAccessionedSequence:R-HSA-452976] TBXT [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9754191] LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene - Homo sapiens
regulatedBy	[NegativeRegulation:453036] Negative regulation by 'POU5F1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9754248] Positive gene expression regulation by 'LEF1,TCF7:CTNNB1:NANOG:TBPL2:TBXT gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9754242] Positive gene expression regulation by 'BMP4 dimer [extracellular region]'
regulationReference	[RegulationReference:9754276] Positive gene expression regulation by 'BMP4 dimer [extracellular region]' Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773645] Tam, Patrick P L, 2022-05-08 [InstanceEdit:9794593] Probst, Simone, 2022-07-18 [InstanceEdit:9796183] Zissel, Lea, 2022-07-18 [InstanceEdit:9796182] Salehin, Nazmus, 2022-05-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-452331
summation	[Summation:452550] The TBXT (T, Brachyury) gene is transcribed to yield mRNA an...
updateTrackers	[UpdateTracker:9846995] Update Tracker - [BlackBoxEvent:452331] Expression of TBXT (T, Brachyury) in the primitive streak - v82:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9846995] Update Tracker - [BlackBoxEvent:452331] Expression of TBXT (T, Brachyury) in the primitive streak - v82:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-9733781] EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene [Reaction:R-HSA-9756671] EOMES and TBXT bind the NANOG gene [Reaction:R-HSA-9756670] EOMES and TBXT bind the POU5F1 (OCT4) gene [Reaction:R-HSA-9756661] EOMES and TBXT bind the SOX2 gene [BlackBoxEvent:R-HSA-9796300] Expression of NOTO in axial mesoderm [BlackBoxEvent:R-HSA-9793921] Expression of DLL1 in paraxial mesoderm [BlackBoxEvent:R-HSA-9793383] Expression of TBX6 in paraxial mesoderm [Reaction:R-HSA-9756666] EOMES and TBXT (T, Brachyury) bind the SNAI1 gene
(hasEvent)	[Pathway:R-HSA-9754189] Germ layer formation at gastrulation
(inferredTo)	[BlackBoxEvent:R-MMU-9754300] Expression of T (Tbxt) in the primitive streak

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